School of Health Sciences: Recent submissions

  • HIV Second-Line Failure and Drug Resistance at High- and Low Level Viremia in Western Ke 
    KANTOR, Rami; DELONG, Allison; SCHREIER, Leeann; REITSMA, Marissa; KEMBOI, Emanuel; ORIDO, Millicent; OBONGE, Salome; BOINETT, Robert; RONO, Mary; EMONYI, Wilfred; BROOKS, Katie; COETZER, Mia; BUZIBA, Nathan; Hogan, Joseph; DIERO, Lameck (HHS Pub lic Access, 2018-11-13)
    Objective: Characterize failure and resistance above and below guidelines-recommended 1,000 copies/mL virologic threshold, upon 2nd-line failure. Design: Cross-sectional study. Methods: Kenyan adults on lopinavir/r ...
  • Genetic structure correlates with ethnolinguistic diversity in eastern and southern Africa 
    Atkinson, Elizabeth G; Dalvie, Shareefa; Pichkar, Yakov; Kalungi, Allan; Majara, Lerato; Stevenson, Anne; Abebe, Tamrat; Akena, Dickens; Alemayehu, Melkam; Ashaba, Fred K; Atwoli, Lukoye; Baker, Mark; Chibnik, Lori B; Creanza, Nicole; Daly, Mark J; Fekadu, Abebaw; Gelaye, Bizu; Gichuru, Stella; Injera, Wilfred E; James, Roxanne; Kariuki, Symon M; Kigen, Gabriel; Koen, Nastassja; Koenen, Karestan C; Koenig, Zan; Kwobah, Edith; Kyebuzibwa, Joseph; Musinguzi, Henry; Mwema, Rehema M; Neale, Benjamin M; Newman, Carter P; Newton, Charles R.J.C; Ongeri, Linnet; Ramachandran, Sohini; Ramesar, Raj; Shiferaw, Welelta; Stein, Dan J; Stroud, Rocky E; Teferra, Solomon; Yohannes, Mary T; Zingela, Zukiswa; Martin, Alicia R (The American Journal of Human Genetics, 2022-09-01)
    African populations are the most diverseinthe world yetare sorelyunderrepresented inmedicalgeneticsresearch. Here, we examine the structure of African populations using genetic and comprehensive multi-generational ...
  • Distribution Of Sickle Cell Trait in ABO/Rhesus Blood Types Among Voluntary Blood Donors in Bungoma County, Kenya 
    Thomas, Wekesa Khisa; Eric Omori Omwenga, Eric Omori; Emonyi, Wilfred Injera (Afr J Lab Haem Transf Sci, 2025-03)
    Background: Sickle cell trait is a haematological inherited disorder wide spread in several geographical regions. Individuals carrying sickle cell trait genes are asymptomatic and are eligible for blood donation; ...
  • Antiretroviral Treatment Interruptions Induced by the Kenyan Postelection Crisis Are Associated With Virological Failure 
    Mann, MPH Marita; Diero, MD Lameck; Kemboi, BSc Emmanuel; Mambo, MSc Fidelis; Rono, BSc Mary; Injera, PhD Wilfred; Delong, MSc Allison; Schreier, MSc Leeann; Kaloustian, MD Kara W.; Sidle, MD John; Buziba, MD Nathan; Kantor, MD Rami (National Institutes of Health Public Access, 2013-10-01)
    Background—Antiretroviral treatment interruptions (TIs) cause suboptimal clinical outcomes. Data on TIs during social disruption are limited. Methods—We determined effects of unplanned TIs after the 2007–2008 Kenyan ...
  • Mosquitocidal Immune Response in BALB/c Mice Is Enhanced When Anopheles gambiae Mucin-1 cDNA Is Co-Administered with Interleukin-12 cDNA 
    Injera, Wilfred E.; Foy, Brian D.; Kabiru, Elphantus W.; Gicheru, Michael M.; Githure, John I.; Beier, John C. (Canadian Center of Science and Education, 2013)
    The midgut of the malaria - transmitting mosquito, Anopheles gambiae, can be targeted by vaccine-induced host immune factors that kill the mosquito after it ingests immunized host blood. The An. gambiae mucin 1 protein (AgMuc1) ...
  • Immunopathological Features Developing in the Mosquito Midgut after Feeding on Anopheles gambiae Mucin-1 / Interleukin-12 cDNA Immunized Mice 
    Injera, Wilfred E.; Kabiru, Elphantus W.; Gicheru, Michael M.; Githure, John I.; Beier, John C. (Universidad de La Frontera, 2013)
    The mosquito midgut is the organ into which the blood meal passes and in which, within a peritrophic membrane secreted by the epithelium, the blood is retained during digestion and absorption. The mosquito midgut is lined ...
  • Induction of Mosquitocidal Activity in Mice Immunized with Anopheles gambiae Midgut cDNA 
    Foy, B. D.; Magalhaes, T.; Injera, W. E.; Sutherland, I.; Devenport, M.; Thanawastien, A.; Ripley, D.; Ca´rdenas-Freytag, L.; Beier, J. C. (American Society for Microbiology, 2023-04)
    Vaccines that induce mosquito-killing (mosquitocidal) activity could substantially reduce the transmission of certain mosquito-borne diseases, especially vaccines against African malaria vectors, such as the mosquito ...
  • A blended genome and exome sequencing method captures genetic variation in an unbiased, high-quality, and cost effective manner 
    Boltz, Toni A; Chu, Benjamin B; Liao, Calwing; Sealock, Julia M; Ye, Robert; Majara, Lerato; Fu, Jack M; Service, Susan; Zhan, Lingyu; Medland, Sarah E; Chapman, Sinéad B; Rubinacci, Simone; DeFelice, Matthew; Grimsby, Jonna L; Abebe, Tamrat; Alemayehu, Melkam; Ashaba, Fred K; Atkinson, Elizabeth G; Bigdeli, Tim; Bradway, Amanda B; Brand, Harrison; Chibnik, Lori B; Fekadu, Abebaw; Gatzen, Michael; Gelaye, Bizu; Gichuru, Stella; Gildea, Marissa L; Hill, Toni C; Huang, Hailiang; Hubbard, Kalyn M; Injera, Wilfred E.; James, Roxanne; Joloba, Moses; Kachulis, Christopher; Kalmbach, Phillip R; Kamulegeya, Rogers; Kigen, Gabriel; Kim, Soyeon (2024-09-09)
    We deployed the Blended Genome Exome (BGE), a DNA library blending approach that generates low pass whole genome (1-4x mean depth) and deep whole exome (30-40x mean depth) data in a single sequencing run. This technology ...
  • Use of Lot Quality Assurance Sampling to Ascertain Levels of Drug Resistant Tuberculosis in Western Kenya 
    Jezmir, Julia, Ted ,Matteo, Edwin, Bethany, Adrian, Lydia , Wilfred ,Jane Cohen, Zignol, Nyakan, Hedt-Gauthier, Gardner, Kamle, Injera, E. Carter, (jezmir, 2016-05-11)
    Objective: To classify the prevalence of multi-drug resistant tuberculosis (MDR-TB) in two different geographic settings in western Kenya using the Lot Quality Assurance Sampling (LQAS) methodology. Design: The ...
  • Cytokine’s Imbalance, the Hallmark of Immune Dysfunction in HIV/AIDS Patients in Rwanda 
    Ngangali, Jean Pierre; Mutesa, Leon; NSANZIMANA, Sabin; Munyemana, Jean Bosco; INJERA, Emonyi Wilfred; KIRTIKA, Patel; GATARE, Swaibu; Rutayisire, Robert; NDISHIMYE, Isabelle Valois; NTAGWABIRA, Edouard; Nkinda, Lilian; CHEMTAI, Alex k. (Research Square, 2021-07-30)
    Cytokines network drive Human Immunodeficiency Virus (HIV) inflammation and pathogenesis. Highly Active Antiretroviral Therapy (HAART) maintains low HIV viral load (VL) but chronic inflammation remains high in HIV subjects ...
  • Prevalence of Non-Tuberculosis Mycobacterium Pulmonary Disease in HIV-1 Patients with Presumptive Pulmonary Tuberculosis in Western Kenya 
    Ochayo, Anne; Wamalwa, Ronald; Barasa, Erick; Zablon, Jeremiah; Sowayo, George; Were, Tom; Gitonga, Godfrey; Shaviya, Nathan (Ethiopian Journal of Health Sciences, 2023-09-01)
    Background: Non-tuberculous mycobacteria (NTMs) are ubiquitous, free-living, environmental saprophytic microorganisms. NTMs belong to the genus Mycobacterium which includes Mycobacterium tuberculosis (MTB). NTMs have lately ...
  • The Occurrence of Alloantibodies among Multitransfused Oncology Patients at Moi Teaching and Referral Hospital 
    Wapukha, Zippy Bunoro; Emonyi, Wilfred Injera; Wanjau, Tabitha (International Journal of Recent Innovations in Medicine and Clinical Research, 2021-11-20)
    This study aimed at determining the presence and type of specific antibodies among multi transfused oncology patients, that causes alloimmunization, the ABO and Rhesus blood group that is most affected by alloimmunization ...
  • COVID- 19 antibody positivity over time and pregnancy outcomes in seven low- and- middle- income countries: A prospective, observational study of the Global Network for Women's and Children's Health Research 
    Goldenberg, Robert L.; Saleem, Sarah; Billah, Sk Masum; Kim, Jean; Moore, Janet L.; Ghanchi, Najia Karim; Haque, Rashidul; Figueroa, Lester; Ayala, Alejandra; Lokangaka, Adrien; Tshefu, Antoinette; Goudar8, Shivaprasad S.; Kavi, Avinash; Somannavar, Manjunath; Esamai, Fabian; Mwenechanya, Musaku; Chomba, Elwyn; Patel, Archana; Das, Prabir; Emonyi, Wilfred Injera; Edidi, Samuel; Deshmukh, Madhavi (An International Journal of Obstetric and Gynacology, 2023-01-02)
    Objectives: To determine COVID- 19 antibody positivity rates over time and rela tionships to pregnancy outcomes in low- and middle- income countries (LMICs). Design: With COVID- 19 antibody positivity at delivery as ...
  • Risk Factors for Red Blood Cell Alloimmunization in Multi-Transfused Oncology Patients at Moi Teaching and Referral Hospital, Kenya 
    Wapukha, Zippy Bunoro; Wanjau, Tabitha Wangui; Emonyi, Wilfred Injera; Marabi, Phidelis Maruti (African Journal of Health Sciences, 2023-06)
    Multiple blood transfusions may result in the production of alloantibodies against one or more red blood cell antigens which might make it more challenging to execute subsequent transfusions. Despite age and gender ...
  • Genetic Characterization of Rhizosphere Bacteria that Inhabit Common Bean Nodules in Western Kenya Soils 
    Wekesa, Clabe; Muoma, John; Ombori, Omwoyo; Maingi, John; Okun, Daniel; Juma, Kelvin; Okoth, Patrick; Wamalwa, Emily; Kollenberg, Mario; Mauti, Eliakim (Applied Microbiology: Open Access Research Article, 2017-03-08)
    With the increasing world population, there is increasing demand for food. This has led to overuse of agricultural farms causing reduced soil fertility and accumulation of phytopathogens. Inorganic fertilizers and ...
  • Abundance and Symbiotic Potential of Common Bean (Phaseolus vulgaris) Nodule Associated Bacteria in Western Kenya Soil 
    Wekesa, Clabe; Okun, Daniel; Juma, Kelvin; Shitabule, Dalmas; Okoth, Patrick; Nyongesa, Peter; Katoo, Athanas; Mulama, Samuel; Wamalwa, Emily; Mahalo, Clarice; Koyo, Moses; Rotich, Aron; Kawaka, Fanuel; Muoma, John (MAYFEB Journal of Agricultural Science, 2016)
    Plant growth-promoting Rhizobacteria are beneficial native soil bacteria that colonize plant roots and result in increased plant growth. Those that colonise the nodules of legumes are known as nodule associated bacteria. ...
  • Factors Contributing To Academic Dishonesty Among Nursing Students In Kenya Medical Training College Western Kenya 
    Wamalwa, Emily M. W.; Okoth, John M.; Ochanda, Damaris (European Journal of Medical and Health Sciences, 2020-08)
    — Introduction: Academic integrity is important in training of nurses since on completion of their studies the nurses will be involved in taking care of lives. Academic dishonesty among nursing students leads to putting ...
  • EFFECTS OF EMERGENCY OBSTETRICS AND NEONATAL CARE TRAINING ON MATERNAL AND PERINATAL OUTCOMES: KAKAMEGA COUNTY, KENYA. 
    Barasa, Ameldah; Mutai, Charles; Kipmerewo, Mary (International journal of advanced research (IJAR), 2016-11)
    Background: Globally, perinatal mortality rate is 19 deaths per1000 births and maternal mortality is 240 per100, 000 live births. In Africa maternal mortality rate is 500 per100, 000 live births and perinatal mortality ...
  • Women’s Perception Of Male’s Support During Perinatal Period 
    Kiptoo1, Sally Jepkosgei; Munyasa, Ameldah Barasa (IOSR Journal of Nursing and Health Science (IOSR-JNHS), 2017-08)
    Abstract : Globally male involvement on maternal health services remains a challenge to effective health care. Maternal deaths arise from pregnancy, childbirth and postnatal complications and this can be reduced by involving ...
  • Knowledge Attitude and Practice on implementation of Nursing process at the County General Hospital, Kakamega County,Kenya 
    Oronje, Sally Jepkosgei; Munyasa, Ameldah Barasa (2018-12)
    Abstract:Nursing process is an organized scientific framework of providing essential health care services to patients that involves orderly and systematic sequence of problem solving techniques towards effective patient care ...

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