• Hemiplegic Patients - The Socio-Economic And Cultural Challenges At Coast Referral County Hospital 

  Eyinda, Johnstone Milimo (Research journali’s Journal of Public Health, 2018-08)

  Background: Hemiplegia is manifestation of muscles paralysis of the body contra-lateral to side of brain pathology. Patients tend to have a unique complex of physical, psychological and social problems. They experience ...
• HIV diversity and drug resistance from plasma and non-plasma analytes in a large treatment programme in western Kenya 

  Kantor, Rami; DeLong, Allison; Balamane, Maya; Schreier, Leeann; Lloyd, Robert M; Injera, Wilfred; Kamle, Lydia; Mambo, Fidelis; Muyonga, Sarah; Katzenstein, David; Hogan, Joseph; Buziba, Nathan; Diero, Lameck (Journal of the International AIDS Society, 2014-11-18)

  Introduction: Antiretroviral resistance leads to treatment failure and resistance transmission. Resistance data in western Kenya are limited. Collection of non-plasma analytes may provide additional resistance information. ...
• Effect of ready-to-use supplementary food on mortality in severely immunocompromised HIV-infected individuals in Africa initiating antiretroviral therapy (REALITY): an open-label, parallel-group, randomised controlled trial 

  Mallewa, Jane; Szubert, Alexander J; Mugyenyi, Peter; Chidziva, Ennie; Thomason, Margaret J; Chepkorir, Priscilla; Abongomera, George; Baleeta, Keith; Etyang, Anthony; Warambwa, Colin; Melly, Betty; Mudzingwa, Shepherd; Kelly, Christine; Agutu, Clara; Wilkes, Helen; Nkomani, Sanele; Musiime, Victor; Lugemwa, Abbas; Pett, Sarah L; Dangarembizi, Mutsa Bwakura-; Prendergast, Andrew J; Gibb, Diana M; Walker, Sarah A.; Berkley, James A (The Lancet HIV, 2018)

  In sub-Saharan Africa, severely immunocompromised HIV-infected individuals have a high risk of mortality during the first few months after starting antiretroviral therapy (ART). We hypothesise that universally providing ...
• Low-coverage sequencing cost-effectively detects known and novel variation in underrepresented populations 

  . Martin, Alicia R; Atkinson, Elizabeth G.; Chapman, Sine´ad B.; Stevenson, Anne; Stroud, Rocky E.; Abebe, Tamrat; Akena, Dickens; Alemayehu, Melkam; Ashaba, Fred K.; Atwoli, Lukoye; Bowers, Tera; Chibnik, Lori B.; Daly, Mark J.; DeSmet, Timothy; Dodge, Sheila; Fekadu, Abebaw; Ferriera, Steven; Gelaye, Bizu; Gichuru, Stella; Injera, Wilfred E.; James, Roxanne; Kariuki, Symon M.; Kigen, Gabriel; Koenen, Karestan C.; Kwobah, Edith; Kyebuzibwa, Joseph; Majara, Lerato; Musinguzi, Henry; Mwema, Rehema M.; Neal, Benjamin M.; Newman, Carter P.; Newton, Charles R.J.C.; Pickrell, Joseph K.; Ramesar, Raj; Shiferaw, Welelta; Stein, Dan J.; Teferra, Solomon; Celia van der Merwe; Merwe, Celia van der; Zingela, Zukiswa; NeuroGAP-Psychosis Study Team (ALUPE UNIVERSITY, 2021-10-25)

  Genetic studies in underrepresented populations identify disproportionate numbers of novel associations. However, most genetic studies use genotyping arrays and sequenced reference panels that best capture variation most ...
• HIV Second-Line Failure and Drug Resistance at High- and Low Level Viremia in Western Ke 

  KANTOR, Rami; DELONG, Allison; SCHREIER, Leeann; REITSMA, Marissa; KEMBOI, Emanuel; ORIDO, Millicent; OBONGE, Salome; BOINETT, Robert; RONO, Mary; EMONYI, Wilfred; BROOKS, Katie; COETZER, Mia; BUZIBA, Nathan; Hogan, Joseph; DIERO, Lameck (HHS Pub lic Access, 2018-11-13)

  Objective: Characterize failure and resistance above and below guidelines-recommended 1,000 copies/mL virologic threshold, upon 2nd-line failure. Design: Cross-sectional study. Methods: Kenyan adults on lopinavir/r ...
• Genetic structure correlates with ethnolinguistic diversity in eastern and southern Africa 

  Atkinson, Elizabeth G; Dalvie, Shareefa; Pichkar, Yakov; Kalungi, Allan; Majara, Lerato; Stevenson, Anne; Abebe, Tamrat; Akena, Dickens; Alemayehu, Melkam; Ashaba, Fred K; Atwoli, Lukoye; Baker, Mark; Chibnik, Lori B; Creanza, Nicole; Daly, Mark J; Fekadu, Abebaw; Gelaye, Bizu; Gichuru, Stella; Injera, Wilfred E; James, Roxanne; Kariuki, Symon M; Kigen, Gabriel; Koen, Nastassja; Koenen, Karestan C; Koenig, Zan; Kwobah, Edith; Kyebuzibwa, Joseph; Musinguzi, Henry; Mwema, Rehema M; Neale, Benjamin M; Newman, Carter P; Newton, Charles R.J.C; Ongeri, Linnet; Ramachandran, Sohini; Ramesar, Raj; Shiferaw, Welelta; Stein, Dan J; Stroud, Rocky E; Teferra, Solomon; Yohannes, Mary T; Zingela, Zukiswa; Martin, Alicia R (The American Journal of Human Genetics, 2022-09-01)

  African populations are the most diverseinthe world yetare sorelyunderrepresented inmedicalgeneticsresearch. Here, we examine the structure of African populations using genetic and comprehensive multi-generational ...
• Distribution Of Sickle Cell Trait in ABO/Rhesus Blood Types Among Voluntary Blood Donors in Bungoma County, Kenya 

  Thomas, Wekesa Khisa; Eric Omori Omwenga, Eric Omori; Emonyi, Wilfred Injera (Afr J Lab Haem Transf Sci, 2025-03)

  Background: Sickle cell trait is a haematological inherited disorder wide spread in several geographical regions. Individuals carrying sickle cell trait genes are asymptomatic and are eligible for blood donation; ...
• Antiretroviral Treatment Interruptions Induced by the Kenyan Postelection Crisis Are Associated With Virological Failure 

  Mann, MPH Marita; Diero, MD Lameck; Kemboi, BSc Emmanuel; Mambo, MSc Fidelis; Rono, BSc Mary; Injera, PhD Wilfred; Delong, MSc Allison; Schreier, MSc Leeann; Kaloustian, MD Kara W.; Sidle, MD John; Buziba, MD Nathan; Kantor, MD Rami (National Institutes of Health Public Access, 2013-10-01)

  Background—Antiretroviral treatment interruptions (TIs) cause suboptimal clinical outcomes. Data on TIs during social disruption are limited. Methods—We determined effects of unplanned TIs after the 2007–2008 Kenyan ...
• Mosquitocidal Immune Response in BALB/c Mice Is Enhanced When Anopheles gambiae Mucin-1 cDNA Is Co-Administered with Interleukin-12 cDNA 

  Injera, Wilfred E.; Foy, Brian D.; Kabiru, Elphantus W.; Gicheru, Michael M.; Githure, John I.; Beier, John C. (Canadian Center of Science and Education, 2013)

  The midgut of the malaria - transmitting mosquito, Anopheles gambiae, can be targeted by vaccine-induced host immune factors that kill the mosquito after it ingests immunized host blood. The An. gambiae mucin 1 protein (AgMuc1) ...
• Immunopathological Features Developing in the Mosquito Midgut after Feeding on Anopheles gambiae Mucin-1 / Interleukin-12 cDNA Immunized Mice 

  Injera, Wilfred E.; Kabiru, Elphantus W.; Gicheru, Michael M.; Githure, John I.; Beier, John C. (Universidad de La Frontera, 2013)

  The mosquito midgut is the organ into which the blood meal passes and in which, within a peritrophic membrane secreted by the epithelium, the blood is retained during digestion and absorption. The mosquito midgut is lined ...
• Induction of Mosquitocidal Activity in Mice Immunized with Anopheles gambiae Midgut cDNA 

  Foy, B. D.; Magalhaes, T.; Injera, W. E.; Sutherland, I.; Devenport, M.; Thanawastien, A.; Ripley, D.; Ca´rdenas-Freytag, L.; Beier, J. C. (American Society for Microbiology, 2023-04)

  Vaccines that induce mosquito-killing (mosquitocidal) activity could substantially reduce the transmission of certain mosquito-borne diseases, especially vaccines against African malaria vectors, such as the mosquito ...
• A blended genome and exome sequencing method captures genetic variation in an unbiased, high-quality, and cost effective manner 

  Boltz, Toni A; Chu, Benjamin B; Liao, Calwing; Sealock, Julia M; Ye, Robert; Majara, Lerato; Fu, Jack M; Service, Susan; Zhan, Lingyu; Medland, Sarah E; Chapman, Sinéad B; Rubinacci, Simone; DeFelice, Matthew; Grimsby, Jonna L; Abebe, Tamrat; Alemayehu, Melkam; Ashaba, Fred K; Atkinson, Elizabeth G; Bigdeli, Tim; Bradway, Amanda B; Brand, Harrison; Chibnik, Lori B; Fekadu, Abebaw; Gatzen, Michael; Gelaye, Bizu; Gichuru, Stella; Gildea, Marissa L; Hill, Toni C; Huang, Hailiang; Hubbard, Kalyn M; Injera, Wilfred E.; James, Roxanne; Joloba, Moses; Kachulis, Christopher; Kalmbach, Phillip R; Kamulegeya, Rogers; Kigen, Gabriel; Kim, Soyeon (2024-09-09)

  We deployed the Blended Genome Exome (BGE), a DNA library blending approach that generates low pass whole genome (1-4x mean depth) and deep whole exome (30-40x mean depth) data in a single sequencing run. This technology ...
• Use of Lot Quality Assurance Sampling to Ascertain Levels of Drug Resistant Tuberculosis in Western Kenya 

  Jezmir, Julia, Ted ,Matteo, Edwin, Bethany, Adrian, Lydia , Wilfred ,Jane Cohen, Zignol, Nyakan, Hedt-Gauthier, Gardner, Kamle, Injera, E. Carter, (jezmir, 2016-05-11)

  Objective: To classify the prevalence of multi-drug resistant tuberculosis (MDR-TB) in two different geographic settings in western Kenya using the Lot Quality Assurance Sampling (LQAS) methodology. Design: The ...
• Cytokine’s Imbalance, the Hallmark of Immune Dysfunction in HIV/AIDS Patients in Rwanda 

  Ngangali, Jean Pierre; Mutesa, Leon; NSANZIMANA, Sabin; Munyemana, Jean Bosco; INJERA, Emonyi Wilfred; KIRTIKA, Patel; GATARE, Swaibu; Rutayisire, Robert; NDISHIMYE, Isabelle Valois; NTAGWABIRA, Edouard; Nkinda, Lilian; CHEMTAI, Alex k. (Research Square, 2021-07-30)

  Cytokines network drive Human Immunodeficiency Virus (HIV) inflammation and pathogenesis. Highly Active Antiretroviral Therapy (HAART) maintains low HIV viral load (VL) but chronic inflammation remains high in HIV subjects ...
• Prevalence of Non-Tuberculosis Mycobacterium Pulmonary Disease in HIV-1 Patients with Presumptive Pulmonary Tuberculosis in Western Kenya 

  Ochayo, Anne; Wamalwa, Ronald; Barasa, Erick; Zablon, Jeremiah; Sowayo, George; Were, Tom; Gitonga, Godfrey; Shaviya, Nathan (Ethiopian Journal of Health Sciences, 2023-09-01)

  Background: Non-tuberculous mycobacteria (NTMs) are ubiquitous, free-living, environmental saprophytic microorganisms. NTMs belong to the genus Mycobacterium which includes Mycobacterium tuberculosis (MTB). NTMs have lately ...
• The Occurrence of Alloantibodies among Multitransfused Oncology Patients at Moi Teaching and Referral Hospital 

  Wapukha, Zippy Bunoro; Emonyi, Wilfred Injera; Wanjau, Tabitha (International Journal of Recent Innovations in Medicine and Clinical Research, 2021-11-20)

  This study aimed at determining the presence and type of specific antibodies among multi transfused oncology patients, that causes alloimmunization, the ABO and Rhesus blood group that is most affected by alloimmunization ...
• COVID- 19 antibody positivity over time and pregnancy outcomes in seven low- and- middle- income countries: A prospective, observational study of the Global Network for Women's and Children's Health Research 

  Goldenberg, Robert L.; Saleem, Sarah; Billah, Sk Masum; Kim, Jean; Moore, Janet L.; Ghanchi, Najia Karim; Haque, Rashidul; Figueroa, Lester; Ayala, Alejandra; Lokangaka, Adrien; Tshefu, Antoinette; Goudar8, Shivaprasad S.; Kavi, Avinash; Somannavar, Manjunath; Esamai, Fabian; Mwenechanya, Musaku; Chomba, Elwyn; Patel, Archana; Das, Prabir; Emonyi, Wilfred Injera; Edidi, Samuel; Deshmukh, Madhavi (An International Journal of Obstetric and Gynacology, 2023-01-02)

  Objectives: To determine COVID- 19 antibody positivity rates over time and rela tionships to pregnancy outcomes in low- and middle- income countries (LMICs). Design: With COVID- 19 antibody positivity at delivery as ...
• Risk Factors for Red Blood Cell Alloimmunization in Multi-Transfused Oncology Patients at Moi Teaching and Referral Hospital, Kenya 

  Wapukha, Zippy Bunoro; Wanjau, Tabitha Wangui; Emonyi, Wilfred Injera; Marabi, Phidelis Maruti (African Journal of Health Sciences, 2023-06)

  Multiple blood transfusions may result in the production of alloantibodies against one or more red blood cell antigens which might make it more challenging to execute subsequent transfusions. Despite age and gender ...
• Genetic Characterization of Rhizosphere Bacteria that Inhabit Common Bean Nodules in Western Kenya Soils 

  Wekesa, Clabe; Muoma, John; Ombori, Omwoyo; Maingi, John; Okun, Daniel; Juma, Kelvin; Okoth, Patrick; Wamalwa, Emily; Kollenberg, Mario; Mauti, Eliakim (Applied Microbiology: Open Access Research Article, 2017-03-08)

  With the increasing world population, there is increasing demand for food. This has led to overuse of agricultural farms causing reduced soil fertility and accumulation of phytopathogens. Inorganic fertilizers and ...
• Abundance and Symbiotic Potential of Common Bean (Phaseolus vulgaris) Nodule Associated Bacteria in Western Kenya Soil 

  Wekesa, Clabe; Okun, Daniel; Juma, Kelvin; Shitabule, Dalmas; Okoth, Patrick; Nyongesa, Peter; Katoo, Athanas; Mulama, Samuel; Wamalwa, Emily; Mahalo, Clarice; Koyo, Moses; Rotich, Aron; Kawaka, Fanuel; Muoma, John (MAYFEB Journal of Agricultural Science, 2016)

  Plant growth-promoting Rhizobacteria are beneficial native soil bacteria that colonize plant roots and result in increased plant growth. Those that colonise the nodules of legumes are known as nodule associated bacteria. ...

View more