Abstract:
Background—Antiretroviral treatment interruptions (TIs) cause suboptimal clinical outcomes.
Data on TIs during social disruption are limited.
Methods—We determined effects of unplanned TIs after the 2007–2008 Kenyan postelection
violence on virological failure, comparing viral load (VL) outcomes in HIV-infected adults with
and without conflict-induced TI.
Results—Two hundred and one patients were enrolled, median 2.2 years after conflict and 4.3
years on treatment. Eighty-eight patients experienced conflict-related TIs and 113 received
continuous treatment. After adjusting for preconflict CD4, patients with TIs were more likely to
have detectable VL, VL >5,000 and VL >10,000.
Conclusions—Unplanned conflict-related TIs are associated with increased likelihood of
virological failure.
Description:
Background—Antiretroviral treatment interruptions (TIs) cause suboptimal clinical outcomes.
Data on TIs during social disruption are limited.
Methods—We determined effects of unplanned TIs after the 2007–2008 Kenyan postelection
violence on virological failure, comparing viral load (VL) outcomes in HIV-infected adults with
and without conflict-induced TI.
Results—Two hundred and one patients were enrolled, median 2.2 years after conflict and 4.3
years on treatment. Eighty-eight patients experienced conflict-related TIs and 113 received
continuous treatment. After adjusting for preconflict CD4, patients with TIs were more likely to
have detectable VL, VL >5,000 and VL >10,000.
Conclusions—Unplanned conflict-related TIs are associated with increased likelihood of
virological failure.
